Next generation mRNA vaccines
Abstract
FUTR bio is a biotechnology company developing a proprietary mRNA vaccine platform to prevent and cure diseases such as infections and cancer. By harnessing the innate immune system, we design single-dose vaccines with faster protective immune responses for humans and animals.
Introduction
“We are at the dawn of a new era for vaccines and immunotherapies.”
Adding a shortcut to accelerate immune responses, our novel platform provides a new way to transform mRNA into more effective vaccines — taking precision medicine to the next level.
We believe it is possible to create revolutionary single-dose vaccines with faster protective immune responses, applicable across infectious disease and oncology indications alike.
Platform & Methods
Our proprietary vaccine technology incorporates natural UTRs and molecular boosters to provide superior immune responses. Inspired by nature, the platform induces faster, regulated and durable immunity through fine-tuned control of the mammalian immune system.
| Fig. 1 — Platform attribute | Effect |
|---|---|
| Natural UTRs | Improved transcript stability |
| Molecular boosters | Faster, stronger immune onset |
| Single-dose design | Reduced dosing burden |
| Modular targets | Infectious disease + oncology |
Fig. 2 — mRNA platform, schematicResults — Pipeline
| Code | Indication | Discovery | In-Vitro (PoC) | In-Vivo (PoC) | IND-Enabling Studies | Clinical |
|---|---|---|---|---|---|---|
| FT00P | Next Gen mRNA Vaccine Platform[Co-Development] | |||||
| FT001 | COVID-19 | |||||
| FT002 | H5N1 | |||||
| FT003 | Fluvid (H5N1 + COVID) |
5 stage timeline
Contributors
Scientific Advisor & Co-founder
Dr. Báfica has led scientific discoveries in the field of immunology and human pathogens, contributing to adjuvants and vaccine development. He developed solid scientific work at world-class institutions such as the National Institutes of Health, Rockefeller University and New York University, and was a nominated member of the Brazilian Academy of Sciences and the National Academy of Medicine. His contributions were recognized with awards including the Howard Hughes Medical Institute Early Career Investigator Competition and GRIP R01 NIH. Dr. Báfica is an associate professor at UFSC and a member of the Halo Team, a United Nations Verified Initiative helping end the pandemic.
Scientific Advisor & Co-founder
Dr. Mansur's breakthrough research in molecular virology has contributed to unraveling innate recognition pathways of DNA and RNA viruses. Prior to forming his group in Brazil, he worked at world-class institutions such as Imperial College London and the University of Cambridge, securing funding for vaccine development and flavivirus biology from sources such as GSK and the Newton Fund / Royal Society. Dr. Mansur is a Brazilian leader in molecular virology and the development of CRISPR-based gene editing tools to understand microbial pathogenesis, and is an associate professor at UFSC.
Scientific Board
Scientific Advisor
Simon Gelman Professor of Anaesthesia (Biochemistry and Molecular Pharmacology) at Harvard Medical School and Professor of Oral Medicine, Infection and Immunity at Harvard School of Dental Medicine. Director of the Center for Experimental Therapeutics and Reperfusion Injury at Brigham and Women's Hospital. Recipient of an NIH MERIT Award, the William Harvey Outstanding Scientist Medal, the AAAS Fellowship, the Society for Leukocyte Biology Bonazinga Award, the ACR Hench Award Lecture, the IUBMB Lecture Medal, the Ross Prize in Molecular Medicine, and the International Eicosanoid Research Foundation's Lifetime Achievement Award, among more than 50 keynote and plenary lectures delivered worldwide.
Scientific Advisor
Professor of Immunobiology at Yale School of Medicine, member of Yale Cancer Center, and Howard Hughes Medical Institute Investigator. His research focuses on the innate immune system, inflammatory response, innate control of adaptive immunity, and host-pathogen interactions. Recipient of the William Coley Award, the Emil von Behring Award, the Blavatnik Award for Young Scientists, the Lewis S. Rosenstiel Award for Distinguished Work in Basic Medical Research, and the Dickson Prize.
Correspondence
Correspondence and inquiries should be directed to:
futr@futr-bio.comSanto Antônio de Lisboa, Florianópolis – SC, Brazil